Caspase - 8 prevents sustained activation of NF - κ B in monocytes undergoing
نویسندگان
چکیده
Institut National de la Santé et de la Recherche Médicale (INSERM) U517, Institut Fédératif de Recherche (IFR) 100, University of Burgundy; Ecole Pratique des Hautes Etudes (EPHE), Faculty of Medicine, 7 boulevard Jeanne d’Arc, 21079 Dijon cedex, France; Centre Hospitalier Universitaire, BP1542, 21034 Dijon cedex, France; INSERM U567, Institut Cochin; Department of Hematology, Cochin Hospital, 27 rue du Faubourg Saint-Jacques, 75679 Paris, France; Department of Pharmacology and biochemistry, Virginia
منابع مشابه
Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation.
Caspases have demonstrated several nonapoptotic functions including a role in the differentiation of specific cell types. Here, we show that caspase-8 is the upstream enzyme in the proteolytic caspase cascade whose activation is required for the differentiation of peripheral-blood monocytes into macrophages. On macrophage colony-stimulating factor (M-CSF) exposure, caspase-8 associates with the...
متن کاملHEMATOPOIESIS Caspase-8 prevents sustained activation of NF- B in monocytes undergoing macrophagic differentiation
1Institut National de la Santé et de la Recherche Médicale (INSERM) U517, Dijon, France; 2Institut Fédératif de Recherche (IFR) 100, University of Burgundy, Dijon, France; 3Ecole Pratique des Hautes Etudes (EPHE), Faculty of Medicine, Dijon cedex, France; 4Centre Hospitalier Universitaire, Dijon cedex, France; 5INSERM U567, Institut Cochin, Paris, France; 6Department of Hematology, Cochin Hospi...
متن کاملCaspase-8 prevents sustained activation of NF- B in monocytes undergoing macrophagic differentiation
1Institut National de la Santé et de la Recherche Médicale (INSERM) U517, Dijon, France; 2Institut Fédératif de Recherche (IFR) 100, University of Burgundy, Dijon, France; 3Ecole Pratique des Hautes Etudes (EPHE), Faculty of Medicine, Dijon cedex, France; 4Centre Hospitalier Universitaire, Dijon cedex, France; 5INSERM U567, Institut Cochin, Paris, France; 6Department of Hematology, Cochin Hospi...
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Fas-associated death domain protein (FADD), caspase-8-related protein (Casper), and caspase-8 are components of the tumor necrosis factor receptor type 1 (TNF-R1) and Fas signaling complexes that are involved in TNF-R1and Fas-induced apoptosis. Here we show that overexpression of FADD and Casper potently activates NF-kB. In the presence of caspase inhibitors, overexpression of caspase-8 also ac...
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